Sedation of Ventilated Patients and Analgesia. 
Sandiumenge, Alberto MD, PhD
One of every 3 patients admitted in an intensive care unit undergoes mechanical 
 ventilation. Sedation and analgesia are required to facilitate patient 
tolerance to such an aggressive procedure, diminishing stress response, 
relieving pain and anxiety, ensuring patient comfort, and facilitating nursing 
 care. However, misuse of sedatives and analgesics may impact negatively on 
critically ill patients. The recognition of the potential for enduring effects 
derived from sedative and analgesic misuse, the availability of new agents, and 
 the growing emphasis on cost containment have led to important changes in the 
way that sedation and analgesia practices are implemented. The aim of the 
present review is to discuss the agents, indications, complications, and most 
 important strategies to optimize the sedation and analgesic practices in the 
intensive care unit.
Clin Pulm Med 2010;17: 290–299
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Dr.Máximo Cuadros Chávez
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